Abstract: The effects of different fertilization levels on the growth, development and water use efficiency of spring millet were studied in semi-humid region. The results show that the height of individual, ears per hectare and 1000-grain weight of spring millet increase with the increase of fertilization amount within a certain range of fertilizer application. At the same time, fertilization induces the water amount in 2-meter soil layer decreasing, and its decreasing range is increasing with the fertilization amount increasing, and the water use efficiency of spring millet increases from 11.56% to 16.24%. When the amount of fertilization over a threshold value, the increasing of fertilizer results in the reduction of yield and water use efficiency of spring millet.