Abstract: In order to explore the effect of water and nitrogen regulation on the yield increase of spring maize by using drip irrigation and fertigation technology under mulch in Hetao Irrigation District. Based on the database of CNKI and Web of science core database, this study conducted a meta-analysis of 399 sets of spring maize yield data, 369 sets of water use efficiency data and 297 sets of nitrogen fertilizer partial productivity data in 40 published literatures that met the criteria. The results showed that the data of spring maize yield, water use efficiency and nitrogen fertilizer partial productivity used in meta-analysis met the normal distribution and there was no publication bias. The analysis results are highly reliable. Compared with low water and low nitrogen, water and nitrogen regulation significantly affected spring maize yield, water use efficiency and partial factor productivity of nitrogen fertilizer. Spring maize significantly increased by 5.94%~19.04%, water use efficiency increased by -10.07%~6.28%, and partial factor productivity of nitrogen fertilizer increased by -39.35%~9.37%. The effect of increasing yield increased first and then decreased with the increase of water and nitrogen, water use efficiency decreased gradually, partial factor productivity of nitrogen fertilizer decreased with the increase of nitrogen application, and increased with the increase of irrigation amount. The effect of regulating irrigation amount on yield increase and water and nitrogen utilization of spring maize was better than that of nitrogen application. Salt content, organic matter content, total nitrogen content and planting density had significant positive effects on spring maize yield. With the increase of annual rainfall or multi-annual average temperature, the water use efficiency decreased with the increase of water and nitrogen, and the increase of nitrogen application had a significant negative effect on the partial productivity of nitrogen fertilizer.The results showed that the irrigation amount of 150~200 mm and the nitrogen application of 180~220 kg·hm^-2 were the best water and nitrogen regulation range in Hetao irrigation area. At the same time, the planting density was less than 66 600 plants·hm^-2, the irrigation quota was less than 30 mm, and the fertilization frequency was more than 5 times. The yield of spring maize could reach 15400~18200.64 kg·hm^-2, and the water use efficiency was between 38.16~50.52 kg·hm^-2·mm^-1. The partial factor productivity of nitrogen fertilizer can reach 55.02~81.20 kg·kg^-1. The study can provide reference for water-saving, yield-increasing and nitrogen-reducing of spring maize in this area.